With an acting career spanning over two decades, Duchovny is a two-time Golden Globe-winner and four-time Emmy nominee. He can currently be seen in a brilliant guest-starring role in Netflix's The Chair created by Amanda Peet starring Sandra Oh. Upcoming, he will be seen alongside Karen Gillan, Leslie Mann and Fred Armisen in the highly anticipated Judd Apatow Netflix comedy, The Bubble, releasing on April 1, 2022, and in the Kenya Barris Netflix comedy, You People, alongside Jonah Hill, Eddie Murphy and Julia Louis-Dreyfus.

Duchovny is a prolific author whose fourth novel, Truly Like Lightning, was published on February 2, 2021. Truly Like Lightning is a heartbreaking meditation on family, religion, sex, greed, human nature, and the vanishing environment of an ancient desert. His previous novels include: the New York Times Best-Seller Holy Cow, Bucky F*cking Dent, and Miss Subways. Each of Duchovny's books have been published by the venerable Farrar, Straus & Giroux. Duchovny also recently released his first Audible Original, The Reservoir, that he both wrote and performed. Set in Manhattan in the early days of the pandemic, The Reservoir is a brilliantly conceived, darkly funny caper of conspiracy and madness that probes the nature of "virality" in our age. Akashic Books will publish the hardcover of The Reservoir alongside Duchovny's chapbook Poems, Lyrics, Flip on June 7, 2022.

Off the success of Truly Like Lightning, Duchovny is partnering with Showtime to develop a television series based on the novel. He will co-write and executive produce the adaptation with Tyler Nilson and Michael Schwartz (The Peanut Butter Falcon), in which he will also star.

As a musician, Duchovny has released three studio albums, Hell or Highwater (2015), Every Third Thought (2018), Gesture/and (2021) and toured globally.

Duchovny grew up in New York City. He graduated from Princeton University summa cum laude with a bachelor's degree in English literature. He then went on to receive an ABD in English Literature from Yale University.